Correlation of Various Prognostic Factors in Breast Cancer

Background: Prognostic factors of breast cancer not only act as a guide to overall prognosis but also determine the need for adjuvant therapy.These factors are interrelated and hormone receptor status is an important determinant of prognosis of ca breast. Objective: The aim of this study was to correlate the various prognostic factors in breast cancer.Tumor size (T) ,nodal status (N) ,grade of the tumour and ER PR status were taken as prognostic factors. Materials and Methods: Mastectomy Specimen of fifty patients of carcinoma breast were studied to ascertain it’s size,status of margin,histology of the tumor ,lymph node metastasis to determine modified Richards Bloomson’s(MRB) score and Nottingham Prognostic Index(NPI). The Estrogen and progesterone receptor status was identified, data was analysed statistically by using Chi-square test and conclusion was drawn. Results: Most of the patients were 40-60 yr of age group, however most were postmenopausal and 40% of the patients had no metastasis in axillary lymph nodes Tumour was hormone receptor positive in two third of the patients.Hormone receptor positivity decreased with increase in size of the tumour , axillary lymph node positivity and grade of the tumour. Hormone receptor positivity increased as the age advances and positivity was more in postmenopausal as compared to premenopausal. Axillary lymph node involvement were increased with size of the tumour also increased size of the tumour leads to increase in the grading of the tumour. Conclusion: More number of patients are presenting in early stage as majority of patients have operable breast cancer. Most of the patients were between 40-60 yr of age which suggest shift towards younger age groups as compared to the traditional presentation of older age. Tumour was hormone receptor positive in two third of the patients. Small size, low grade and tumours without axillary lymph node metastasis have more chances of receptor positivity.